Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx
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چکیده
منابع مشابه
Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the HBV genome (covalently-closed circular DNA, cccDNA) is inhibited by the structural maintenance of chromosome 5/6 complex (Smc5/6), and that a key function of HBx is to redirect the DNA-dam...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2021
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2020.09.019